NCT03522532

Dental Restorations Effect on Oxidative Status of the Gingival Crevicular Fluid

Redox Interactions Between Dental Restorations and Gingival Crevicular Fluid

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 88 (actual)
• Sponsor: Ervin Taso · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The goal of the study was to ascertain the influence of dental caries and teeth position as well as the type and amount of the applied dental materials (DMs) on the oxidative stress (OS) status in gingival crevicular fluid (GCF).

Detailed description

Six DMs were tested by investigators, each sealed in one session: amalgam (Amg), zinc phosphate cement (ZnPhC), zinc polycarboxylate cement (ZnPoC), glass ionomer cement (GIC) and composites, Tetric EvoCeram (TEC) and Beautifil (BF). The study included 88 dental outpatients. Oxidative stress parameters, including malondialdehyde (MDA), glutathione (GSH) and total superoxide dismutase (tSOD) activity were measured in GCF, before (day 0) and after treatment (7th and 30th day). Antagonistically positioned healthy teeth were used as a control.

Conditions

• Pharmacological Action

Interventions

Type	Name	Description
PROCEDURE	Amalgam placement	Before the Amg was sealed GCF was taken, and then taken again on the 7th and 30th days after the applied treatment.
PROCEDURE	Tetric EvoCeram placement	Before the TEC was sealed GCF was taken, and then taken again on the 7th and 30th days after the applied treatment.
PROCEDURE	Beautifil placement	Before the BF was sealed GCF was taken, and then taken again on the 7th and 30th days after the applied treatment.
PROCEDURE	Zinc phosphate cement placement	Before the ZPhC was sealed GCF was taken, and then taken again on the 7th and 30th days after the applied treatment.
PROCEDURE	Zinc polycarboxylate cement placement	Before the ZPoC was sealed GCF was taken, and then taken again on the 7th and 30th days after the applied treatment.
PROCEDURE	Glass ionomer cement placement	Before the GIC was sealed GCF was taken, and then taken again on the 7th and 30th days after the applied treatment.

Timeline

• Start date: 2016-10-01
• Primary completion: 2017-09-01
• Completion: 2017-11-01
• First posted: 2018-05-11
• Last updated: 2018-05-11

Locations

1 site across 1 country: Serbia