NCT03522220

Augmentation of Neuronal Network Plasticity in Schizophrenia

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: Universitätsklinikum Hamburg-Eppendorf · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Current pathophysiological models of schizophrenia focus on disconnectivity of distributed neuronal systems to explain the multitude of psychic symptoms. However, therapeutic strategies targeting this specific pathobiology are lacking. Our recent work provides strong evidence that complex video-game training interventions facilitate fronto-hippocampal structural and functional connectivity within 2 months in healthy subjects. The planned project transfers this knowledge into a training study in schizophrenic patients to counteract disease-related disconnectivity. Underlying mechanisms and behavioral effects are extensively parametrized by resting state functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), spectroscopy and clinical short- and long-term outcome.

Conditions

• Schizophrenia
• Healthy

Interventions

Type	Name	Description
BEHAVIORAL	3D navigation video game intervention	Participants intensively train with a video game (Super Mario DS)
BEHAVIORAL	video game intervention without 3D navigation	Participants train with a video game (Super Mario Bros)
BEHAVIORAL	No 3D navigation	Participants read on a kindle device (control group)

Timeline

• Start date: 2016-09-01
• Primary completion: 2019-07-31
• Completion: 2019-12-31
• First posted: 2018-05-11
• Last updated: 2018-06-06

Locations

1 site across 1 country: Germany