NCT03517007

The DETOURS Trial: De-escalating Empiric Treatment: Opting Out of Rx for Selected Patients With Suspected Sepsis - Opt-Out Protocol Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 762 (actual)
• Sponsor: Duke University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The objective of this study is to implement an opt-out protocol to guide appropriate de-escalation of antibiotics in qualifying patients. The protocol, determined over the course a year with the help of a large, well-rounded expert panel, will be used by pharmacists to recommend de-escalation of antibiotics to hospital providers. Providers can then decide whether or not to follow the recommendation in determining the best treatment pathway for his or her patient.

Conditions

• Antibiotic Stewardship

Interventions

Type	Name	Description
OTHER	Opt-Out Protocol	Should an eligible patient pass the safety screen and be randomized to the intervention arm of the trial, the designated pharmacist will approach the patient's primary provider in charge of antibiotic decision-making The pharmacist will inform the provider the patient's antibiotics can be de-escalated unless the provider opts out.

Timeline

• Start date: 2018-09-12
• Primary completion: 2020-08-03
• Completion: 2020-08-10
• First posted: 2018-05-07
• Last updated: 2025-02-06

Locations

10 sites across 1 country: United States