NCT03514550

Effects of Anesthesia on Immunity in Cancer

Immunomodulatory Effects of Volatile and Total Intravenous Anesthesia for Patients With Renal Cancer

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Meshalkin Research Institute of Pathology of Circulation · Network
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is a comparative study of the cellular immunity response of patients operated on for kidney cancer under total intravenous and inhalational anesthesia.

Detailed description

The severity of perioperative immunosuppression is directly proportional to the degree of surgical stress. A series of experimental and clinical studies indicate a different effect of certain types of anesthesia on immunity. It is believed that surgical stress itself opens an opportunity for the recurrence of oncological diseases precisely due to the immunosuppressive effect. The aim of present pilot clinical study is to test a hypothesis that total intravenous anesthesia as superior to inhalational anesthesia in term of its effects on cell immunity among patients with kidney cancer.

Conditions

• Surgery
• Renal Cancer

Interventions

Type	Name	Description
DRUG	Propofol	Propofol will be used for anesthesia during surgery
DRUG	Sevoflurane	Sevoflurane will be used for anesthesia during surgery
PROCEDURE	Epidural block	Epidural catheterization Th9-Th10, ropivacaine for perioperative analgesia

Timeline

• Start date: 2018-05-14
• Primary completion: 2019-04-01
• Completion: 2019-05-20
• First posted: 2018-05-02
• Last updated: 2019-06-03

Locations

1 site across 1 country: Russia