Trials / Completed
CompletedNCT03508466
Mechanism of Hypersensitivity Reactions to Iron Nanomedicines
Investigation of the Underlying Mechanism of Hypersensitivity Reactions to Intravenous Iron Nanomedicines in Patients With Previous Hypersensitivity Reaction Compared to Controls - a Cross-sectional Study
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 42 (actual)
- Sponsor
- University Hospital, Basel, Switzerland · Academic / Other
- Sex
- All
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Not accepted
Summary
Iron deficiency is common and when oral treatment is not sufficient intravenous application is indicated. Hypersensitivity to intravenous iron nanomedicines is rare but does occur and little is known about the underlying mechanism but complement activation has been suggested. This is a purely exploratory study as it is not yet known whether in vitro complement activation can be stimulated by titration with iron preparations. These data will provide first empirical evidence of whether and to what extent complement activation occurs in this population.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | hypersensitivity reaction | Previous hypersensitivity reaction |
Timeline
- Start date
- 2017-10-01
- Primary completion
- 2019-12-31
- Completion
- 2019-12-31
- First posted
- 2018-04-25
- Last updated
- 2020-02-25
Locations
1 site across 1 country: Switzerland
Source: ClinicalTrials.gov record NCT03508466. Inclusion in this directory is not an endorsement.