NCT03507062

Effect of Crystalloids With Different SID on pH, and Urinary Electrolytes During General Anesthesia

Effect of Crystalloids With Different SID on Hemodilution, Plasmatic Acid Base Equilibrium and Urinary Electrolytes in Patients During General Anesthesia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (actual)
• Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The present study will investigate variations in acid base equilibrium caused by the administration of four different crystalloids with increasing strong ion difference (0.9% saline, Ringer's lactate, Ringer's acetate, plasmalyte-like solution) in patients during general anesthesia. The same crystalloid will be administered throughout the surgery. In order to assess the effect of hemodilution, every patient will receive two fluid boli with different volumes of the same solution. pH and strong ion variations, togher with the renal response to acid base disturbances, will be analysed.

Conditions

• SID
• Acid-Base Imbalance

Interventions

Type	Name	Description
OTHER	0.9% saline administration	Each patient will receive 0.9%saline based on attending physician decision
OTHER	Ringer's lactate administration	Each patient will receive Ringer's lactate based on attending physician decision
OTHER	Plasmalyte-like solution administration	Each patient will receive Plasmalyte-like solution based on attending physician decision

Timeline

• Start date: 2017-12-10
• Primary completion: 2022-06-30
• Completion: 2023-07-30
• First posted: 2018-04-24
• Last updated: 2024-03-26

Locations

1 site across 1 country: Italy