NCT03501251

Efficacy and Safety of Ascending Dosages of Moxidectin and Moxidectin-albendazole Against Trichuris Trichiura

Efficacy and Safety of Ascending Dosages of Moxidectin and Moxidectin-albendazole Against Trichuris Trichiura in Adolescents: a Randomized Controlled Trial

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 286 (actual)
• Sponsor: Swiss Tropical & Public Health Institute · Academic / Other
• Sex: All
• Age: 16 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

The study rationale is to provide evidence on effective doses of moxidectin and/or moxidectin-albendazole in adolescents (16-18 years old) infected with Trichuris trichiura. The study will take place on Pemba Island, Tanzania.

Conditions

• Trichuris Trichiura; Infection

Interventions

Type	Name	Description
DRUG	Moxidectin 8mg	Participants will receive the tablet with clean water and a package of biscuits.
DRUG	Moxidectin 8 mg + albendazole 400 mg	Participants will receive the tablets with clean water and a package of biscuits.
DRUG	Moxidectin 16 mg	Participants will receive the tablets with clean water and a package of biscuits.
DRUG	Moxidectin 16 mg + albendazole 400 mg	Participants will receive the tablets with clean water and a package of biscuits.
DRUG	Moxidectin 24 mg	Participants will receive the tablets with clean water and a package of biscuits.
DRUG	Moxidectin 24 mg + albendazole 400 mg	Participants will receive the tablets with clean water and a package of biscuits.
OTHER	Placebo	Participants will receive the tablet with clean water and a package of biscuits.

Timeline

• Start date: 2018-07-03
• Primary completion: 2018-08-11
• Completion: 2018-08-11
• First posted: 2018-04-18
• Last updated: 2018-08-14

Locations

1 site across 1 country: Tanzania