NCT03498352

Rest Ventilatory Parameters Predict Morbidity and Mortality in Thoracic Surgery

Rest Ventilatory Parameters Predict Morbidity and Mortality in Patients Undergoing Thoracic Surgery

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 366 (actual)
• Sponsor: St. Anne's University Hospital Brno, Czech Republic · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

Cardiopulmonary exercise testing is recommended for preoperative evaluation and risk stratification of lung resection candidates. Ventilatory efficiency (VE/VCO2 slope) has been shown to predict morbidity and mortality in lung resection candidates and has been shown superior to peak oxygen consumption (VO2). Patients with increased VE/VCO2 during exercise also exhibit increased VE/VCO2 ratio and decreased end-tidal CO2 at rest. Our first hypothesis is that rest ventilatory parameters predict morbidity and mortality in patients undergoing thoracic surgery. VE/VCO2 is well correlated with ventilation-perfusion mismatch, therefore it may be useful in hypoxemia prediction during one-lung ventilation during thoracic surgery. Our second hypothesis is that patients with high VE/VCO2 will be prone to hypoxemia development during one-lung ventilation.

Conditions

• Pulmonary Complication
• Cardiovascular Complication

Interventions

Type	Name	Description
PROCEDURE	Thoracic surgery	Lung resection surgery

Timeline

• Start date: 2017-05-01
• Primary completion: 2021-01-31
• Completion: 2021-01-31
• First posted: 2018-04-13
• Last updated: 2021-02-10

Locations

2 sites across 1 country: Czechia