Trials / Unknown
UnknownNCT03498235
Effects of Sevoflurane and Propofol on Optic Nerve Sheath Diameter During Laparoscopic Gynecologic Surgery
Randomized,Double-Blind Trial A Comparative Analysis of the Effects of Sevoflurane and Propofol on Optic Nerve Sheath Diameter During Steep Trendelenburg Position and Pneumoperitoneum for Laparoscopic Gynecologic Surgery
- Status
- Unknown
- Phase
- EARLY_Phase 1
- Study type
- Interventional
- Enrollment
- 110 (estimated)
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University · Academic / Other
- Sex
- Female
- Age
- 18 Years – 60 Years
- Healthy volunteers
- Not accepted
Summary
Intracranial pressure（ICP) increases during laparoscopic gynecologic surgery increase (ICP) and may alter optic nerve sheath diameter(ONSD).This study measures ONSD in different team because sevoflurane and propofol have different effects on ICP.Half of participants will receive sevoflurane anesthesia,while the other half undergo propofol anesthesia.
Detailed description
Due to the anatomical and physiological characteristics of optic nerve sheath ,ONSD increases when ICP rises. Sevoflurane and propofol have different effects on ICP.When sevoflurane concentration \>1.1 minimum alveolar concentration（MAC),ICP increases because of cerebral vasodilatation；on the other hand ,propofol constricts the blood vessels and ICP decreases. ICP increases during laparoscopic gynecologic surgery because of steep Trendelenburg position and pneumoperitoneum . Meanwhile,sevoflurane affects self regulation of cerebral blood flow on the way of dose dependent,but propofol has no effects on self regulation of cerebral blood flow.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Sevoflurane | In Team Sevoflurane,patients undergo sevoflurane. |
| DRUG | Propofol | In Team Propofol ,anesthesia is maintained with propofol |
Timeline
- Start date
- 2018-03-01
- Primary completion
- 2020-06-01
- Completion
- 2020-06-01
- First posted
- 2018-04-13
- Last updated
- 2020-06-23
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT03498235. Inclusion in this directory is not an endorsement.