NCT03496285

Accumbofrontal Tract Study in 2 Populations of Patients With Anorexia Nervosa and Obsessional Compulsive Disorder and Healthy Volunteer

Multimodal MRI Study of Accumbofrontal Tract in Anorexia Nervosa and Obessional Compulsive Disorder : Search for Structural and Functional Changes Between Orbito-frontal Cortex and Accumbens Nucleus Subdivisions

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Poitiers University Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Restrictive anorexia nervosa and TOCs are psychiatric diseases which shares a common pathophysiological substrate We hypothesize that anorexia patients and patients with OCD have structural and functional changes in the accumbofrontal tract. The main objective of this study will be to compare the structure and the connectivity of this tract in MRI with diffusion sequences (DTI tractography) and resting-state, in 3 distinct populations of anorexic patients, patients with OCD and healthy patients. The role of the accumbo-frontal tract in the cortico-striato-hypothalamo-cortical circuit seems to be established. DTI tractography will allow the measurement of functional anisotropy (FA), a parameter that evaluates the diffusion of water molecules along the white matter fibers, and therefore the potential alteration of the studied tract. Resting state sequences will allow to estimate the BOLD signal and the functionality of the tract.

Conditions

• Accumbo Frontal Tract

Interventions

Type	Name	Description
RADIATION	Multimodal MRI with diffusion sequence for anorexia nervosa patient	Multimodal MRI with diffusion sequence, resting state, T2, T1 without gadolinium contrast
RADIATION	Multimodal MRI with diffusion sequence for obsessional compulsive disorder patient	Multimodal MRI with diffusion sequence, resting state, T2, T1 without gadolinium contrast
RADIATION	Multimodal MRI with diffusion sequence for healthy volunteer	Multimodal MRI with diffusion sequence, resting state, T2, T1 without gadolinium contrast

Timeline

• Start date: 2018-05-09
• Primary completion: 2021-11-24
• Completion: 2021-11-24
• First posted: 2018-04-12
• Last updated: 2022-03-31

Locations

1 site across 1 country: France