NCT03496103

Innate Neutrophilic Nasal Inflammation in a Pollen Exposure Chamber

Induction of Innate Neutrophilic Nasal Inflammation in a Pollen Exposure Chamber

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 29 (actual)
• Sponsor: The University of Texas Medical Branch, Galveston · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

In this study subjects self recorded nasal and ocular symptoms scores from exposure to ragweed pollen in an Allergen Challenge Chamber (ACC). This single site study of seasonal allergic rhinitis was designed to enroll up to 35 participants. These participants would be age 18-70, male and female, with a mixture of ethnic groups. The study would involve 2 phases: Screening and Exposure. In the Exposure phase, participants were exposed to pollen for up to 180 minutes.

Detailed description

This was a study to evaluate self recorded nasal and ocular allergy symptom scores from exposure to ragweed pollen in an Allergen Challenge Chamber (ACC). This single site study of seasonal allergic rhinitis was designed to enroll up to 35 participants. These participants would be age 18-70, male and female, with a mixture of ethnic groups. The study would involve 2 phases: Screening and Exposure. In the Exposure phase, participants were exposed to pollen for up to 180 minutes. For allergic participants, qualification symptom scores at 120 minutes of exposure determined if ACC exposure would be continued.

Conditions

• Allergic Rhinitis

Interventions

Type	Name	Description
BIOLOGICAL	ragweed pollen	three hours ragweed pollen in a allergen exposure chamber

Timeline

• Start date: 2016-02-29
• Primary completion: 2016-03-12
• Completion: 2016-03-12
• First posted: 2018-04-12
• Last updated: 2018-04-12