NCT03494088

Mycobiome Evaluation in Children With Autism & GI Symptoms

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: The University of Texas Health Science Center, Houston · Academic / Other
• Sex: All
• Age: 4 Years – 16 Years
• Healthy volunteers: Accepted

Summary

This study's primary aim is to explore the potential differences in the gut mycobiome of children with autism spectrum disorder compared to otherwise healthy children. The secondary objective of this study is to evaluate whether the presence of specific species of fungi (e.g. Candida tropicalis, C. albicans, or Saccharomyces cerevisiae), in stool: 1) correlates with increased gastrointestinal symptoms; 2) correlates with evidence of increased behavioral problems (as assessed by the Aberrant Behavior Checklist or Social Responsiveness Scale-2); or 3) plays the same role as a constituent of commensal gut microflora as in normal controls. The scale indicates severity of social deficits in the autism spectrum as mild, moderate or severe. Additionally, the study aims to compare the fecal and oral fungi in these children because many fecal mycobiota are felt to originate in the oropharynx.

Conditions

• Autism
• Gastrointenstinal Symptoms

Timeline

• Start date: 2018-03-22
• Primary completion: 2019-05-01
• Completion: 2019-05-01
• First posted: 2018-04-11
• Last updated: 2018-05-14

Locations

1 site across 1 country: United States