NCT03493256

Novel BIochemical Markers for Predicting Type 2 NEurological Complications of Surgical Coronary Revascularization (BINER)

Novel BIochemical Markers for Predicting Type 2 NEurological Complications of Surgical Coronary Revascularization (BINER): a Prospective Cohort Study.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: Collegium Medicum w Bydgoszczy · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: —

Summary

In this single center prospective cohort study a total of 100 patients scheduled for elective off-pump CABG will be recruited. They will be allocated to one study and one control group according to the presence or absence of postoperative type 2 neurological complications. The two groups will be compared in terms of serum concentrations of glial fibrillary acidic protein (GFAP), neuroserpin (NSP), phosphorylated axonal neurofilament subunit H (pNfH) and visinin-like protein 1 (VILIP-1) at the time of skin incision and closure as well as 24 hours and 7 days following surgery. Diagnostic performance of these markers for predicting type 2 neurological complications of off-pump CABG will be assessed.

Conditions

• Neurological Complication of Procedure (Disorder)

Interventions

Type	Name	Description
OTHER	exposure to type 2 neurological complications	exposure to postoperative cognitive dysfunction (POCD) or postoperative delirium (POD), or both concurrently.

Timeline

• Start date: 2018-04-01
• Primary completion: 2019-03-01
• Completion: 2019-03-01
• First posted: 2018-04-10
• Last updated: 2020-02-05

Locations

1 site across 1 country: Poland