NCT03492294

The Role of Music Stimulation in Disorders of Consciousness State: an fMRI Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 11 (actual)
• Sponsor: Hangzhou Normal University · Academic / Other
• Sex: All
• Age: 21 Years – 61 Years
• Healthy volunteers: —

Summary

The aim of the present study was to evaluated the neural effect of music on the cerebral activation in unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) by using functional magnetic resonance imaging (fMRI).

Detailed description

Background: Sensory stimulations were used widely to evaluate the preserved cerebral functions for these patients with disorders of consciousness. Among these, the most alerting or common stimuli are probably familiar voice and music. Objective: The aim of the present study was to evaluated the neural effect of music on the cerebral activation in unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) by using functional magnetic resonance imaging (fMRI). Methods: Eleven severely brain-damaged patients (6 UWS and 5 MCS) were assessed by functional magnetic resonance imaging while they were exposed under the condition of their personal music. To examine the prognostic value of these patients, longitudinal behavioral assessments were repeatedly conducted by means of the CRS-R after fMRI acquisition.

Conditions

• Vegetative State
• Minimally Conscious State

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	functional magnetic resonance imaging	Patients with disorders of consciousness were assessed by functional magnetic resonance imaging while they were exposed under the condition of music.

Timeline

• Start date: 2008-12-01
• Primary completion: 2017-11-01
• Completion: 2018-04-01
• First posted: 2018-04-10
• Last updated: 2018-04-10

Locations

1 site across 1 country: China