NCT03491995

A Unique Regimen for Treatment of Helicobacter Pylori Infection

A Unique Quadruple Regimen for of Helicobacter Pylori

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 600 (estimated)
• Sponsor: Sherief Abd-Elsalam · Academic / Other
• Sex: All
• Age: 21 Years
• Healthy volunteers: Not accepted

Summary

The triple treatment including Proton pump inhibitor (PPI) -clarithromycin and amoxicillin or metronidazole was proposed 30 years ago at the first Maastricht conference to treat helicobacter pylori (H. pylori) infection and since that time, it has become the universal and standard treatment for helicobacter pylori. However, the efficacy of this triple regimen has been seriously challenged, and they are gradually becoming ineffective

Detailed description

Growing rates of treatment failure are observed worldwide and the eradication rate of triple therapy has declined over the past few decades. Helicobacter pylori infection has become increasingly resistant to traditional first line treatment regimens because of emerging antibiotic resistance coupled with poor patient compliance with completing the treatment course that decrease H. pylori eradication rates .So there is a considerable interest in evaluating new antibiotic combinations and regimens .

Conditions

• Helicobacter Infections

Interventions

Type	Name	Description
DRUG	Quadruple therapy	Moxifloxacin, omeprazole sodium bicarbonate, nitazoxanide, doxycyclin
DRUG	Classic treatment	Omeprazole, amoxycillin, clarithromycin

Timeline

• Start date: 2018-04-01
• Primary completion: 2023-04-01
• Completion: 2023-04-01
• First posted: 2018-04-09
• Last updated: 2018-04-10

Locations

1 site across 1 country: Egypt