NCT03490955

Effects of Black Pepper on the Absorption of Nutrients in Vegetables

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: University of Massachusetts, Amherst · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The objective of this project is to determine the extent to which eating black pepper together with vegetables increase the absorption of carotenoids (a class of important nutrients) in the vegetables such as beta-carotene.

Detailed description

Black pepper has multiple health-promoting effects, many of which are associated with the relatively high levels of piperine it contains. Piperine can enhance the oral bioavailability of nutraceuticals in foods due to its inhibitory activity on drug metabolizing enzymes such as cytochrome P450 and p-glycoprotein in the gastrointestinal mucosa. This decreases the first-pass metabolism of nutraceuticals thus increasing their levels in the systemic circulation. Numerous studies in both animals and humans have validated the efficacy of piperine in boosting nutraceutical bioavailability. However, most of these studies utilized highly purified sources of both piperine and nutraceuticals, and therefore do not provide direct evidence on the ability of black pepper (used as a spice) to enhance the bioavailability of nutraceuticals in real foods.

Conditions

• Black Pepper
• Absorption
• Carotenoid

Interventions

Type	Name	Description
OTHER	salad dressing (canola oil) and black pepper	Subjects will consume a vegetable salad with black pepper and dressing (canola oil) one time in the morning
OTHER	salad dressing (canola oil)	Subjects will consume a vegetable salad with dressing (canola oil) one time in the morning
OTHER	black pepper	Subjects will consume a vegetable salad without dressing (canola oil) but with black pepper one time in the morning
OTHER	salad	Subjects will consume a vegetable salad without dressing (canola oil) and without black pepper one time in the morning
OTHER	Salad dressing (olive oil) and black pepper	Subjects will consume a vegetable salad with black pepper and dressing (olive oil) one time in the morning
OTHER	Salad dressing (corn oil) and black pepper	Subjects will consume a vegetable salad with black pepper and dressing (corn oil) one time in the morning
OTHER	Salad dressing (sunflower oil) and black pepper	Subjects will consume a vegetable salad with black pepper and dressing (sunflower oil) one time in the morning
OTHER	Salad dressing (flaxseed oil) and black pepper	Subjects will consume a vegetable salad with black pepper and dressing (flaxseed oil) one time in the morning

Timeline

• Start date: 2018-09-06
• Primary completion: 2019-06-15
• Completion: 2019-11-30
• First posted: 2018-04-06
• Last updated: 2021-04-30

Locations

1 site across 1 country: United States