NCT03489564

Mitochondrial Capacity in Pregnant Women

The Effect of Physical Activity on in Vivo and in Vitro Mitochondrial Capacity in Pregnant Women

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 20 (actual)
• Sponsor: Pennington Biomedical Research Center · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This Pilot \& Feasibility study will test the hypothesis that pregnant women who are more active will have better functioning mitochondria in vivo (higher ATPmax, via 31P-MRS), which will be positively related to maternal and infant mitochondrial function in vitro (higher oxygen consumption rates in primary myotubes and umbilical cord derived mesenchymal stem cells, respectively). Twenty pregnant women (10 active and 10 sedentary) will be recruited in the first trimester of pregnancy determined from self-reported physical activity and assessment by activity monitors. Placental biospecimens will be collected during delivery for other molecular mitochondrial analyses.

Conditions

• Pregnancy Related
• Physical Activity

Interventions

Type	Name	Description
BEHAVIORAL	Active	No behavioral intervention included but the exposure is level of physical activity. Individuals in the Active group will be categorized by their own routine physical activity levels.
BEHAVIORAL	Sedentary	No behavioral intervention included but the exposure is level of physical activity. Individuals in the Sedentary group will be categorized by their own routine physical activity levels.

Timeline

• Start date: 2018-03-19
• Primary completion: 2020-02-11
• Completion: 2020-02-11
• First posted: 2018-04-05
• Last updated: 2022-09-27

Locations

1 site across 1 country: United States