NCT03476421

R1vascular Hepatectomy for HCC Patients

Is R1 Vascular Hepatectomy for Hepatocellular Carcinoma Oncologically Adequate?

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 327 (actual)
• Sponsor: Humanitas Clinical and Research Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Since the previous decade, the authors introduced the R1 vascular (R1vasc) resection for the treatment of hepatocellular carcinoma (HCC), and colorectal liver metastases (Torzilli et al. J Am Coll Surg 2005; Viganò et al. Ann Surg Oncol 2016; Torzilli et al. Surgery 2017). However, oncological reliability of tumor exposure in surgery for HCC remains controversial since it has never been validated. The aim of the study is to determine the oncological adequacy of R1vasc hepatectomy in patients with HCC.

Detailed description

A prospective cohort of patients who underwent hepatectomy for HCC between January 2005 and December 2015 is reviewed. The following definitions are adopted: R0 is any resection with at least 1 mm of negative margin; R1vasc is any resection with tumor exposure due to the detachment from major intrahepatic vessel (1st/2nd order glissonean pedicles and hepatic vein at caval confluence); R1-parenchymal (R1par) is any resection with tumor exposure at parenchymal margin.

Conditions

• Hepatocellular Carcinoma

Interventions

Type	Name	Description
PROCEDURE	Hepatic resection	Surgery of the liver; removal of a part of the liver

Timeline

• Start date: 2005-01-01
• Primary completion: 2015-12-31
• Completion: 2018-01-01
• First posted: 2018-03-26
• Last updated: 2018-03-26