NCT03472469

MAST Trial: Multi-modal Analgesic Strategies in Trauma

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 1,561 (actual)
• Sponsor: The University of Texas Health Science Center, Houston · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

This is a comparative effectiveness study of current pain management strategies in acutely injured trauma patients. Two different multi-modal, opioid minimizing analgesic strategies will be compared \[original multimodal pain regimen (MMPR) compared to multi-modal analgesic strategies for trauma (MAST) MMPR\].

Conditions

• Nonspecific Pain Post Traumatic Injury

Interventions

Type	Name	Description
DRUG	Acetaminophen IV/PO	Acetaminophen 1g IV/PO every 6 hours
DRUG	Acetaminophen PO	Acetaminophen 1g PO every 6 hours
DRUG	Ketorolac	Ketorolac 30mg IV once
DRUG	Celebrex	Celebrex 200mg PO every 12 hours
DRUG	Naproxen	Naproxen 500mg PO every 12 hours
DRUG	Tramadol	Tramadol 100mg PO every 6 hours
DRUG	Pregabalin	Pregabalin 100mg PO every 8 hours
DRUG	Gabapentin	Gabapentin 300mg PO every 8 hours
DRUG	Lidocaine	Lidocaine patch every 12 hours
DRUG	Opioids	Opioid options include: Oral Opioids (Codeine, Tramadol, Hydrocodone, Oxycodone, Methadone, Morphine, Hydromorphone); Transdermal Opioid (Fentanyl); Intravenous Opioids (Morphine, Hydromorphone, Fentanyl)
DRUG	Regional anesthesia	Regional anesthesia

Timeline

• Start date: 2018-04-02
• Primary completion: 2019-07-03
• Completion: 2019-07-03
• First posted: 2018-03-21
• Last updated: 2021-06-18
• Results posted: 2021-06-10

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study