NCT03471585

Effects of THC on Emotional Memory Retrieval

The Effects of Δ⁹-Tetrahydrocannabinol on the Retrieval of Emotional Memories

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: University of Chicago · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The main purpose of this study was to examine the effects of THC on the retrieval of emotional and neutral memories in healthy young adults. Secondary experiments included the effects of THC on the encoding of object and scene stimuli and a novel working memory task.

Detailed description

Here, the investigators aimed to investigate the effects of THC (15 mg) on the retrieval of negative, neutral, and positive memories. The study used a placebo-controlled, within-subjects, crossover design with 24 participants. In each experimental arm, participants attend a session to encode stimuli, a second session 48 hours later in which their memories are tested for the stimuli from the first session followed by the encoding of object-scene stimuli and a working memory test, and a third session 48 hours later in which memory for the object-scene stimuli is tested. In the second session, two hours prior to memory testing, THC or placebo is administered. On the first and second sessions subjects complete mood questionnaires.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	THC	A capsule that contains 15 mg of THC as well as dextrose filler administered 2 hours prior to memory testing.
DRUG	Placebo oral capsule	A capsule that contains only dextrose filler administered 2 hours prior to memory testing.

Timeline

• Start date: 2017-02-15
• Primary completion: 2017-10-04
• Completion: 2017-10-04
• First posted: 2018-03-20
• Last updated: 2019-05-30

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study