NCT03471468

Kinetics of Microparticles Under Chemotherapy in Patients With Gastric or Pancreatic Cancer

Study of the Kinetics of Microparticles Under Chemotherapy in Patients With Gastric or Pancreatic Cancer

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 3 (actual)
• Sponsor: Poitiers University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Microparticles have recently emerged as a thrombotic risk marker with a potential role in determining which patients are at greatest risk for developing thrombosis. Available data show an increase in the level of microparticles in cancer patients who are undergoing chemotherapy for solid tumors with a possible link to their thrombogenic state. Our study focuses on the kinetics of microparticles under chemotherapy in patients with pancreatic or gastric cancer by serial measurements of microparticles procoagulant activity. Detailed Description: The impact of chemotherapy on microparticles expression will be assessed by measuring their procoagulant activity on blood samples taken during the course of chemotherapy. The thrombotic risk will be evaluated by the score of Khorana in parallel. Microparticles expression in patients with thrombosis will be compared to that in other patients.

Conditions

• Pancreatic Cancer
• Gastric Cancer

Interventions

Type	Name	Description
PROCEDURE	kinetics of microparticles under chemotherapy	Blood samples done before chemotherapy and 6 hours later for each of six chemotherapies required by the protocol.

Timeline

• Start date: 2018-07-23
• Primary completion: 2020-01-02
• Completion: 2020-01-02
• First posted: 2018-03-20
• Last updated: 2020-02-17

Locations

1 site across 1 country: France