Trials / Completed
CompletedNCT03470363
Effect of Spinal or Sevoflurane Anesthesia on Neutrophil Activation During Knee Surgery With Pneumatic Tourniquet
Effect of Spinal or Sevoflurane Anesthesia on Neutrophil Activation After Tourniquet Induced Ischemia-reperfusion in Knee Surgery
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 40 (actual)
- Sponsor
- University of Liege · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Aim of study : Assessement of neutrophil activation during ischemia reperfusion associated with tourniquet use for total knee arthroplasty. This activation was compared in a group of patient scheduled for spinal anesthesia and for sevoflurane anesthesia
Detailed description
Aim of study : Assessement of neutrophil activation during ischemia reperfusion associated with tourniquet use for total knee arthroplasty. This activation was compared in a group of patient scheduled for spinal anesthesia and for sevoflurane anesthesia This activation was assessed by plasma myeloperoxidase and elastase measurements in four consecutive blood samples during and after surgery (before surgical incision and 1, 3, 24 hours following tourniquet release.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Sevoflurane Volatile Liquid | |
| DRUG | Bupivacaine / SUFentanil |
Timeline
- Start date
- 2016-01-01
- Primary completion
- 2018-03-01
- Completion
- 2018-03-01
- First posted
- 2018-03-19
- Last updated
- 2020-03-26
Source: ClinicalTrials.gov record NCT03470363. Inclusion in this directory is not an endorsement.