NCT03469089

Touchscreen-based Cognitive Tests in Healthy Volunteers

Touchscreen-based Cognitive Tests in Assessment of Ketamine-induced Cognitive Deficits in Healthy Volunteers

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: University of Eastern Finland · Academic / Other
• Sex: Male
• Age: 20 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This phase Ib study aims to evaluate applicability of touchscreen-based cognitive test battery for assessment of ketamine-induced schizophrenia-like cognitive deficits in healthy volunteers. Additionally, the study aims to assess whether ketamine-induced cognitive deficits are reversed by modafinil using touchscreen-based test battery for testing of cognition.

Detailed description

Ketamine-induced schizophrenia-like cognitive deficits in healthy volunteers are measured by using touchscreen-based cognitive tests. In addition, the study aims to assess whether ketamine-induced cognitive deficits detected by touchscreen-based cognitive tests are reversed by modafinil.

Conditions

• Cognitive Symptom
• Schizophrenia

Interventions

Type	Name	Description
DRUG	Ketamine 0.58	Ketamine (0.23 mg/kg bolus + 0.58 mg/kg/h)
DRUG	Ketamine 0.31	Ketamine (0.12 mg/kg bolus + 0.31 mg/kg/h)
DRUG	Modafinil	Modafinil tablet 100 mg placed in a capsule
DRUG	Placebo for ketamine	0.9 % NaCl infusion solution
DRUG	Placebo for modafinil	Placebo capsule for modafinil capsule

Timeline

• Start date: 2018-03-12
• Primary completion: 2018-05-16
• Completion: 2019-12-31
• First posted: 2018-03-19
• Last updated: 2018-10-16

Locations

1 site across 1 country: Finland