NCT03467997

Mental Stress & Diesel Exhaust on Cardiovascular Health

Effects of Mental Stress and Diesel Exhaust on Cardiovascular Health

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 22 (estimated)
• Sponsor: University of Washington · Academic / Other
• Sex: All
• Age: 22 Years – 49 Years
• Healthy volunteers: Accepted

Summary

This study uses an experimental design to conduct a double-blind, randomized, crossover study where participants receive both diesel exhaust and a mental stress test in a controlled setting. My hypothesis is that the synergistic effect of stress and air pollution will result in higher levels of stress and inflammation (measured via biological markers) as well as poorer cardiovascular disease related outcomes compared to the independent effect of each exposure separately.

Conditions

• Blood Pressure
• Inflammation
• Catecholamines

Interventions

Type	Name	Description
BEHAVIORAL	Trier social stress test	Subjects are asked to give a 5 minute speech on a topic selected by the investigator. Then they are asked to subtract 7 from 758.
OTHER	Diesel exhaust	Diesel exhaust is an air pollutant found in the environment and produced by cars, trucks and other transportation modes (e.g. trains, planes).

Timeline

• Start date: 2018-03-22
• Primary completion: 2020-01-01
• Completion: 2020-01-01
• First posted: 2018-03-16
• Last updated: 2018-11-05

Locations

1 site across 1 country: United States