NCT03467893

Evaluation of Rebound Effect After Withdrawal of Proton Pump Inhibitor in Geriatric Population

Evaluation of Rebound Effect After Withdrawal of Proton Pump Inhibitor After 8 Weeks of Treatment in Geriatric Population

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 30 (actual)
• Sponsor: Fondation Hôpital Saint-Joseph · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

Proton pump inhibitor are frequently used and are short term well tolerated ; but few studies show there are adverse event in long term prescription like fracture or pulmonary infection to Clostridum difficile. The fact is that multi medication in old patient increase the iatrogenic risk and decrease the medication compliance. The Proton pump inhibitor (PPI)are overused in this patient category.Several studies suggest the existence of a rebound effect when people were treated more than 8 weeks ; this effect seems to appear around 14 days after with hyperacidity symptoms. But there are no studies about old patient. So in this context the aim of the study is to evaluate the prevalence of rebound effect occurence after the end of PPI 8 weeks treatment.

Conditions

• Proton Pump Inhibitor

Interventions

Type	Name	Description
DRUG	Antacids	number aof antacids treatment after PPI stop

Timeline

• Start date: 2017-06-10
• Primary completion: 2017-07-01
• Completion: 2018-02-28
• First posted: 2018-03-16
• Last updated: 2019-08-06

Locations

1 site across 1 country: France