NCT03467061

The Effect of Dietary Nitrate on the Oral Microbiome

The Effect of Dietary Nitrate on the Oral Microbiota, Markers of Nitric Oxide Bioavailability and Cardiovascular Health in in Young and Older Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 101 (actual)
• Sponsor: University of Exeter · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

This study evaluates whether dietary manipulation of the oral microbiota modulates cardiovascular health through effects on nitric oxide bioavailability.

Detailed description

Nitric oxide is an important molecule for human health because it controls blood flow and blood pressure. With aging, our ability to make nitric oxide gets worse and our blood pressure tends to increase. We can help the body produce more nitric oxide by supplementing the diet with vegetables, such as beetroot juice, which contains high amounts of nitrate. This has been shown to improve blood flow and blood pressure. The bacteria inside our mouths play an important role in helping convert the ingested nitrate to nitric oxide. The reason for this study is to find out whether there are differences in oral bacteria between young and older adults, and how the oral bacterial community and blood flow and blood pressure might change when diet is supplemented with natural, nitrate-rich beetroot juice and when we use antibacterial mouthwash. This study will help us understand how the bacteria inside our mouths might be useful for keeping us healthy.

Conditions

• Cardiovascular Health
• Identify Oral Bacteria Responsible for Nitrate Reduction

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Nitrate-rich beetroot juice	concentrated beetroot juice
DIETARY_SUPPLEMENT	Nitrate-depleted beetroot juice	concentrated beetroot juice
OTHER	Mouthwash	2 x 10 mL antibacterial mouthwash per day for 14 days

Timeline

• Start date: 2018-01-10
• Primary completion: 2021-05-06
• Completion: 2021-05-06
• First posted: 2018-03-15
• Last updated: 2021-05-27

Locations

1 site across 1 country: United Kingdom