NCT03466684

BIA Guided-fluid Management in Postinjury Open Abdomen

Bioelectrical Impedance Analysis Guided-Fluid Management Promotes Primary Fascial Closure of Postinjury Open Abdomen

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 140 (actual)
• Sponsor: Nanjing PLA General Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Fluid overload (FO), resulting from high volume fluid therapy, is frequent and contributes to excessive visceral edema, delayed fascial closure, and adverse outcomes among postinjury open abdomen (OA) patients. Bioelectrical impedance analysis (BIA) is a promising tool in monitoring fluid status and FO. Thus, we sought to investigate the efficacy of BIA-directed resuscitation among postinjury OA patients.

Conditions

• Damage Control
• Trauma Abdomen
• Acute Compartment Syndrome

Interventions

Type	Name	Description
OTHER	BIA-guided fluid resuscitation protocol	In both groups, a multi-frequency BIA with eight tactile electrodes (Inbody S10 Biospace, Biospace Co. Ltd., Seoul, Korea) was used to assess body fluid status every 6h within the first 72h after admission to the ICU and daily for a period of 4 days. BIA recording was not adjusted by clinicians in fluid restrict, pharmacological and mechanical means of therapy. In contrast, in group BIA, fluid resuscitation protocol with adjustment determined according to HL measured by BIA.
OTHER	Traditional fluid resuscitation protocol	Traditional fluid resuscitation strategy determined by treating clinicians according to usual clinical parameters.

Timeline

• Start date: 2013-01-01
• Primary completion: 2017-12-31
• Completion: 2018-03-31
• First posted: 2018-03-15
• Last updated: 2018-08-31