NCT03461068

Exogenous Ketones and Glucose Tolerance

The Effect of Exogenous Ketone Monoester Supplement on Glycemic Response to an Oral Glucose Tolerance Test

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: University of British Columbia · Academic / Other
• Sex: All
• Age: 30 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The ketone body beta-hydroxybutyrate is produced during prolonged fasting or when endogenous carbohydrate stores are depleted and can be used as an alternative fuel source. Exogenous beta-hydroxybutyrate, in the form of a ketone monoester, is proposed to have glucose-lowering potential but this has not been adequately studied. The purpose of this study is to determine whether supplementing with an acute dose of ketone monoester can improve the glycemic response to an oral glucose tolerance test in individuals with impaired fasting glucose.

Conditions

• Ketones
• Dietary Supplements

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Ketone monoester	Acute ingestion of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate prior a 2-hour oral glucose tolerance test.
DIETARY_SUPPLEMENT	Placebo	Acute ingestion of a taste-matched placebo prior a 2-hour oral glucose tolerance test.

Timeline

• Start date: 2018-03-26
• Primary completion: 2018-10-03
• Completion: 2018-10-15
• First posted: 2018-03-09
• Last updated: 2019-04-18

Locations

1 site across 1 country: Canada