NCT03459248

Metoclopramide-Ondansetron vs. Metoclopramide Therapy for Treatment of Nausea and Vomiting Post Laparoscopic Surgery

Metoclopramide-Ondansetron Dual Therapy vs Metoclopramide Monotherapy for Treatment of Nausea and Vomiting Post Laparoscopic Cholecystectomy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Makassed General Hospital · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

The incidence of postoperative nausea and vomiting (PONV) after general anesthesia is up to 30% when inhalational anesthetics are used with no prophylaxis. This makes PONV one of the most common complaints following surgery under general anesthesia, together with postoperative pain.

Detailed description

This is a prospective, randomized, double-blind controlled clinical trial. Written informed consent will be obtained from patients. Patients will be randomly assigned using the sealed envelope technique into 2 equal groups: Group 1: Patients will receive 10 mg metoclopramide with 4mg ondansetron before induction of general anesthesia. Group 2: Patients will receive 10 mg metoclopramide before induction of general anesthesia.

Conditions

• Postoperative Nausea and Vomiting

Interventions

Type	Name	Description
OTHER	Dual therapy	combination of 10 mg metoclopramide with 4 mg ondansetron
OTHER	Monotherapy	10 mg metoclopramide
OTHER	General anesthesia	Induction of general anesthesia will be performed followed by endotracheal intubation.

Timeline

• Start date: 2018-02-15
• Primary completion: 2019-07-31
• Completion: 2019-07-31
• First posted: 2018-03-08
• Last updated: 2019-09-27

Locations

1 site across 1 country: Lebanon