NCT03456687

Effects of Exenatide on Motor Function and the Brain

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 5 (actual)
• Sponsor: University of Florida · Academic / Other
• Sex: All
• Age: 40 Years – 77 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this research study is to investigate how the brain and motor behavior changes Parkinson's Disease (PD) over time in response to Exenatide. In previous clinical trials, PD patients have experienced symptomatic improvement on Exenatide and literature suggests it may help slow the progression of Parkinson's. Both will be evaluated in this study.

Detailed description

Participants will receive baseline testing to confirm a diagnosis of Parkinson's Disease and to determine eligibility in the research study. All of the participants in this study will receive the study drug (Exenatide). The study drug will be provided at the end of the first visit, and participants will be administered the drug once per week for the duration of the study (1 year). During the research study the following test may occur: (1) questionnaires about quality of life and depression; (2) tests to measure strength and motor function; (3) tests to measure cognition; (4) orientation session to learn a precision gripping task; (5) functional MRI scan of the brain; (6) structural MRI scan of the brain.

Conditions

• Parkinson's Disease

Interventions

Type	Name	Description
DRUG	Exenatide	Exenatide will be administered through a subcutaneous injection once per week for the duration of the study (1 year).

Timeline

• Start date: 2018-06-05
• Primary completion: 2020-10-16
• Completion: 2021-08-25
• First posted: 2018-03-07
• Last updated: 2022-09-16

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study