NCT03451877

TGFB1 And LAMA1 Gene Polymorphisms in High Myopia

TGFB1 and LAMA1 Gene Polymorphisms in Turkish Children With High Myopia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 151 (actual)
• Sponsor: Ege University · Academic / Other
• Sex: All
• Age: 3 Years – 13 Years
• Healthy volunteers: Accepted

Summary

The investigators aimed to investigate TGFB1 and LAMA1 gene polymorphisms in children with high myopia in order to determine the genetic basis of large myopic shifts causing severe visual impairment and complications. Seventy-four children with high myopia (≥6 diopters \[D\]; study group) and 77 emmetropic children (±0.5D; control group) were included. Genetic and polymorphism analyses were performed in the Medical Genetics Laboratory using DNA purified from the patients' blood samples.

Conditions

• High Myopia
• Gene Mutations

Interventions

Type	Name	Description
GENETIC	TGFB1 AND LAMA1 GENE POLYMORPHISMS	we evaluated polymorphisms in the LAMA1 (rs2089760) and TGFB1 (rs4803455) genes in children younger than 13 years of age with ≥6 D myopia in an attempt to further elucidate the genetic basis of high myopia.

Timeline

• Start date: 2012-12-01
• Primary completion: 2016-12-01
• Completion: 2017-06-01
• First posted: 2018-03-02
• Last updated: 2018-03-05