NCT03449706

Accurate Staging of Immuno-virological Dynamics During Acute HIV Infection

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 70 (estimated)
• Sponsor: University Hospital, Ghent · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

In this prospective longitudinal study we aim to assess how immunologic and viral aspects of the human immunodeficiency virus (HIV) viral reservoir, established during early HIV infection and responsible for viral rebound at treatment interruption, evolve in individuals who start combination anti-retroviral therapy (cART) during acute seroconversion. Recently infected patients will be selected based on Fiebig staging for an in depth sampling protocol at different timepoints during a 2 year follow up period. Colonbiopsies, lymphnode resection, lumbar puncture, leucapheresis and repeated peripheral venous blood-draws will be performed. Immunological, virological and genome expression analysis will be performed on the gathered samples.

Conditions

• HIV
• Seroconversion, HIV

Interventions

Type	Name	Description
DRUG	Early combination anti-retroviral treatment	Patients are started on treatment to supress the HIV virus in the phase of acute seroconversion.

Timeline

• Start date: 2017-09-01
• Primary completion: 2028-01-01
• Completion: 2028-01-01
• First posted: 2018-02-28
• Last updated: 2025-01-14

Locations

1 site across 1 country: Belgium