Trials / Completed
CompletedNCT03447600
Diet-Induced Variability in Appetite (DIVA)
The Impact of Weight Loss Through Alternate Day Fasting on Homeostatic and Hedonic Appetite Control and Eating Behaviour: a Proof of Concept Randomized Controlled Trial
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 54 (actual)
- Sponsor
- University of Leeds · Academic / Other
- Sex
- Female
- Age
- 18 Years – 55 Years
- Healthy volunteers
- Accepted
Summary
The aim of this study is to test the hypothesis that dietary weight loss (WL) through alternate day fasting (ADF) will enhance appetite control, health markers and wellbeing following WL compared to standard daily calorie restriction (CR).
Detailed description
This is a proof of concept randomized controlled trial in which overweight/obese females will be randomised to a dietary weight loss intervention (ADF or CR) to achieve ≥5% WL. Behavioural measures of appetite control including ad libitum intake after a fixed meal, body composition, resting metabolic rate, measured physical activity and daily energy expenditure, sleep quality, hedonic food reward and eating behaviour traits will be assessed before, during and after the WL intervention in those who reach the target weight loss within 12 weeks. After weight loss phase, participants will be given standard healthy eating and physical activity advice for weight maintenance and body weight will be followed up after weight loss at 12 months.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | Alternate Day Fasting | 25% daily energy requirements every other day until study completion at \>/=5% weight loss which is an average of 12 weeks. |
| BEHAVIORAL | Continuous dietary restriction | 25% daily energy requirements every other day until study completion at \>/=5% weight loss which is an average of 12 weeks. |
Timeline
- Start date
- 2018-03-01
- Primary completion
- 2018-12-12
- Completion
- 2018-12-12
- First posted
- 2018-02-27
- Last updated
- 2020-11-06
Locations
1 site across 1 country: United Kingdom
Source: ClinicalTrials.gov record NCT03447600. Inclusion in this directory is not an endorsement.