NCT03447002

Urine Levels of Metanephrin and Normetanephrin in Patients With Frequent Ventricular Premature Complex

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: TC Erciyes University · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: —

Summary

Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.

Detailed description

Premature ventricular complex is a very frequent arrhythmia. Suggested mechanisms for PVCs are reentry, triggered activity, and enhanced automaticity. Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Half-lives of catecholamines are very short and rather changeable. Therefore, 24 hours urine levels of catecholamines are the more sensitive than plasma levels. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.

Conditions

• Premature Ventricular Contraction

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	24 hours urine levels metanephrine and normetanephrine	24 hours rhythm recording and 24 hours urine measurement

Timeline

• Start date: 2018-02-15
• Primary completion: 2019-09-30
• Completion: 2019-09-30
• First posted: 2018-02-27
• Last updated: 2019-11-14

Locations

1 site across 1 country: Turkey (Türkiye)