NCT03442023

Different Oral Colonization of Gram-negative Bacteria in ICU Patients When Using Chlorhexidine at 0.12% Versus Chlorhexidine at 2.0%

Differences Between Oral Colonization Rates of Gram-negative Bacteria in ICU Patients When Using Chlorhexidine Mouthwash at 0.12% Versus Chlorhexidine Mouthwash at 2.0%

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 74 (estimated)
• Sponsor: Universidad de Guanajuato · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study will assess the utility of different chlorhexidine mouthwash concentrations on ICU patients to decolonize their oral cavities from gram-negative bacteria, since this is a non-desirable condition that leads to higher mortality rates and longer hospitalization times. One group will receive the 0.12% chlorhexidine mouthwash and the other group will receive the 2% chlorhexidine mouthwash.

Conditions

• Chlorhexidine
• Ventilator Associated Pneumonia

Interventions

Type	Name	Description
DRUG	Chlorhexidine gluconate at 2%	Mouth Rinse with Chlorhexidine gluconate at 2% every 12 hours, one week.
DRUG	Chlorhexidine gluconate at 0.12%	Mouth Rinse with Chlorhexidine gluconate at 0.12% every 12 hours, one week.

Timeline

• Start date: 2019-02-01
• Primary completion: 2019-11-01
• Completion: 2019-12-01
• First posted: 2018-02-22
• Last updated: 2019-03-11

Locations

1 site across 1 country: Mexico