Trials / Completed
CompletedNCT03441919
Activation Innate Immune System in Type 1 Diabetes
Activation of the Innate Immune System and Vascular Inflammation in Patients With Type 1 Diabetes
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 66 (actual)
- Sponsor
- Radboud University Medical Center · Academic / Other
- Sex
- All
- Age
- 20 Years – 60 Years
- Healthy volunteers
- Accepted
Summary
Hyperglycemia is a well-known cardiovascular risk factor. It has also been shown that episodes of hyperglycemia increase the risk for cardiovascular diseases despite return to normoglycemia, a phenomenon termed 'glycemic or metabolic memory'. The molecular mechanism underlying this phenomenon remains unclear. Cardiovascular events, such as myocardial infarction and stroke are caused by atherosclerosis, which is characterized by low grade inflammation of the vascular wall, including accumulation of innate immune cells such as monocytes and macrophages. The investigators hypothesize that chronic hyperglycemia shifts intracellular metabolism of innate immune cells towards glycolysis and changes the epigenetic state of (progenitors of) innate immune cells (monocytes and macrophages), which reprograms these cells towards a more aggressive, pro-atherogenic phenotype, thereby accelerating atherosclerosis. In this study, the investigators aim to test this hypothesis. This research will reveal whether the innate immune cells of patients with chronic hyperglycemia show a durable shift in intracellular metabolism and epigenetic changes and whether this associates with vascular inflammation.
Conditions
- Diabetes Mellitus, Type 1
- Cardiovascular Diseases
- Innate Immune System
- Inflammation
- Metabolism Disorder, Glucose
Interventions
| Type | Name | Description |
|---|---|---|
| RADIATION | PET-CT (positron emission tomography - computer tomography) | PET-CT to determine vascular inflammation |
| DIAGNOSTIC_TEST | Blood drawn | Blood drawn |
Timeline
- Start date
- 2018-01-18
- Primary completion
- 2019-01-21
- Completion
- 2019-01-21
- First posted
- 2018-02-22
- Last updated
- 2019-04-02
Locations
1 site across 1 country: Netherlands
Source: ClinicalTrials.gov record NCT03441919. Inclusion in this directory is not an endorsement.