NCT03441438

Mechanisms of Alcohol Sensitivity in AERD

Mechanisms of Alcohol Sensitivity in Aspirin Exacerbated Respiratory Disease

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University of Virginia · Academic / Other
• Sex: All
• Age: 21 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine what type of reactions in the body may be responsible for the respiratory symptoms that occur when patients with Aspirin Exacerbated Respiratory Disease (AERD) drink alcoholic beverages. These reactions are most often seen with red wine.

Detailed description

This is a prospective trial of approximately 60 subjects with AERD to explore the mechanisms behind the physiologic reactions that occur when drinking alcoholic beverages. At various time points patients will be asked to ingest a variety of substances found in red wine after which blood and urine markers of the reaction will be measured.

Conditions

• Aspirin-Sensitive Asthma With Nasal Polyps
• Samter's Syndrome

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Water	Serum and urine markers will be obtained after drinking 5 oz of water
DIETARY_SUPPLEMENT	Red wine	Serum and urine markers will be obtained after drinking 5 oz of water
DIETARY_SUPPLEMENT	Polyphenolic Compounds	Serum and urine markers will be obtained after consuming 100 mg of provinols powder

Timeline

• Start date: 2018-05-01
• Primary completion: 2018-09-01
• Completion: 2018-09-01
• First posted: 2018-02-22
• Last updated: 2018-05-07

Locations

1 site across 1 country: United States