NCT03439540

Influence of Plantago Major on Mineral Metabolism and Selected Biochemical Parameters in Obese Women

The Study on the Influence of Plantago Species (Plantago Major) on Adipose Tissue Content, Mineral Metabolism and Other Selected Biochemical Parameters of Blood in Obese Women

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: Poznan University of Life Sciences · Academic / Other
• Sex: Female
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Effect of oral supplementation with Plantago major on cardiometabolic risk factors and mineral content and lifestyle in obese women: double-blind, randomized clinical trial.

Detailed description

The purpose of the study is to determine whether oral Plantago major supplementation affects cardiometabolic risk factors, mineral content, and lifestyle in obese women. In previous research it was found that the Plantago maxima extract counteracts the development of adipose tissue in rats on a high-fat diet. In addition, antioxidative, anti-inflammatory and antidiabetic action of Plantago has been demonstrated. Moreover, it has been shown that Plantago influences lipolysis in obese mice and ameliorates metabolic processess in obese rats. The project is due to evaluate the effect of oral supplementation with selected Plantago species - Plantago major in obese patients on: * the content of minerals in blood, hair and urine * total cholesterol, HDL and LDL cholesterol and triglycerides blood concentration, * blood glucose and insulin concentration, * blood pressure, * anthropometric parameters: body mass, body height, waist and hip circumferences * body content measured by bioimpedance: % of fat tissue and % of muscle tissue * quality of life 70 subjects will be randomized into two groups and receive oral Plantago major extract (the first group) or oral placebo (the second group) once daily for 12 weeks. At baseline and at completion (after 12 weeks) fasting blood, urine and hair samples will be collected and abovementioned parameters will be measured.

Conditions

• Obesity

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Plantago major	Individuals receive Plantago major daily, for 12 weeks
DIETARY_SUPPLEMENT	Placebo	Individuals receive placebo daily, for 12 weeks

Timeline

• Start date: 2018-03-01
• Primary completion: 2020-12-01
• Completion: 2021-09-30
• First posted: 2018-02-20
• Last updated: 2022-04-05

Locations

1 site across 1 country: Poland