Trials / Completed
CompletedNCT03438812
Dehydroepiandrosterone Maintain Mitochondrial Quality of Cumulus Cells in Poor Ovarian Responders
The Role of Dehydroepiandrosterone in the Maintenance of Mitochondrial Quality of Cumulus Cells in Poor Ovarian Responders
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 66 (actual)
- Sponsor
- Kaohsiung Veterans General Hospital. · Academic / Other
- Sex
- Female
- Age
- 25 Years – 45 Years
- Healthy volunteers
- Not accepted
Summary
To investigate whether the DHEA supplementation could improve mitochondrial quality in poor ovarian responders
Detailed description
Women who underwent in vitro fertilization (IVF) treatment participated, including normal ovarian responders (NORs) and poor ovarian responders (PORs). PORs were assigned to receive DHEA supplementation or not before the IVF cycle. For all patients, cumulus cells (CCs) were obtained after oocyte retrieval. In the CCs, mRNA expression of mitochondria-related genes was measured. To compare the mRNA expression of mitochondria-related genes in the CCs among the three groups.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIETARY_SUPPLEMENT | dehydroepiandrosterone (DHEA) | Participants take DHEA 90 mg daily for two months at least before in vitro fertilization cycles. |
Timeline
- Start date
- 2017-09-06
- Primary completion
- 2019-12-31
- Completion
- 2019-12-31
- First posted
- 2018-02-20
- Last updated
- 2021-02-18
Locations
1 site across 1 country: Taiwan
Source: ClinicalTrials.gov record NCT03438812. Inclusion in this directory is not an endorsement.