NCT03436329

Reduced Dissemination of Tumor Cells With Primary Ligation of the Vein in Patients With Lung Cancer

Reduced Dissemination of Tumor Cells With Primary Ligation of the Vein in Patients With Lung Cancer: A Multi-centre Randomized Controlled Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: West China Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to assess the impact of the sequence of vessel interruption in lung cancer patients on tumor cell spread and patient survival by using peripheral blood circulating tumor cells.

Detailed description

Circulating tumor cells (CTCs) in the peripheral blood can be a biomarker to predict tumor recurrence and survival. Handling the tumor during a surgery may promote the release of CTCs into the bloodstream. Therefore, in a surgery of cancer, interruption of the vein before ligation of the artery may be justified. This multi-center randomized controlled trial is to assess the impact of the sequence of vessel interruption in lung cancer patients on tumor cell spread and patient survival by using peripheral blood CTCs.

Conditions

• Lung Cancer
• Surgery
• Circulating Tumor Cell

Interventions

Type	Name	Description
PROCEDURE	Vein ligation first	During this procedure, patients undergo lobectomy with the pulmonary vein ligated first.
PROCEDURE	Artery ligation first	During this procedure, patients undergo lobectomy with the pulmonary artery ligated first.

Timeline

• Start date: 2016-12-01
• Primary completion: 2018-05-31
• Completion: 2020-12-31
• First posted: 2018-02-19
• Last updated: 2020-10-12

Locations

1 site across 1 country: China