Trials / Completed
CompletedNCT03432728
Salivary Antioxidant Capacity Before and After Complete Dental Rehabilitation
Salivary Antioxidant Capacity of Children With Severe Early Childhood Caries (S-ECC) Before and After Complete Dental Rehabilitation
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 40 (actual)
- Sponsor
- Riyadh Colleges of Dentistry and Pharmacy · Academic / Other
- Sex
- All
- Age
- 60 Months – 72 Months
- Healthy volunteers
- Accepted
Summary
Salivary samples were obtained from 20 children in their fifth year of life diagnosed S-ECC and 20 age and sex matched controls. Complete dental rehabilitation under general anesthesia was performed for the 20 children with S-ECC, and follow up salivary samples were obtained one week and three months post operatively. The TAC was measured using a commercially available Oxygen Radical Absorbance Antioxidant Assay measurement kit (Zen-Bio ORAC™, AMS Biotechnology, Abington UK).
Detailed description
Background: The association of total salivary antioxidant capacity (TAC) to severe early childhood caries (S-ECC) has been studied in the past. It is not clear if TAC is an indicator of the inflammatory response to the lesion or a marker of the disease. Aim: This study aimed to measure the salivary TAC levels in children with early childhood caries before and after dental treatment and compare the results to caries free children. Methodology: Salivary samples were obtained from 20 children in their fifth year of life diagnosed S-ECC and 20 age and gendersex matched controls. Complete dental rehabilitation under general anesthesia was performed for the 20 children with S-ECC, and follow up salivary samples were obtained one week and three months post operatively. The TAC was measured using a commercially available Oxygen Radical Absorbance Antioxidant Assay measurement kit (Zen-Bio ORAC™, AMS Biotechnology, Abington UK).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Dental rehabilitation under general anesthesia | Dental treatment of all teeth affected by dental caries in a single visit under general anesthesia |
Timeline
- Start date
- 2016-01-25
- Primary completion
- 2017-01-28
- Completion
- 2017-12-31
- First posted
- 2018-02-14
- Last updated
- 2018-02-14
Locations
1 site across 1 country: Saudi Arabia
Source: ClinicalTrials.gov record NCT03432728. Inclusion in this directory is not an endorsement.