Trials / Unknown
UnknownNCT03430414
Analysis of Biopsies With Antibody Mediated Rejection According to the Therapy Response
Transcriptome Analysis of Stored Biopsy Samples in Clinically Precisely Phenotyped Therapy-responders Versus Non-responders Diagnosed With Antibody Mediated Rejection
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 50 (estimated)
- Sponsor
- Thomas Mueller · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
In adult kidney transplant recipients a therapy-responder and non-responder phenotype by antibody mediated rejection will be precisely defined according to clinical and histological characteristics such as creatinine, proteinuria and Banff-classification. Twenty-five patients will be selected each in the therapy-responder and non-responder group. Their stored Formalin Fixed Paraffin Embedded (FFPE) biopsies will be (re)-classified according to the most recent Banff classification. Using Nanostring Technology the gene transcription of therapy-responders versus non-responders will be analyzed and compared to serological and clinical parameters.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Transcriptome Analysis | Transcriptome Analysis of Formalin Fixed Paraffin Embedded biopsies |
Timeline
- Start date
- 2018-02-15
- Primary completion
- 2018-03-01
- Completion
- 2018-04-30
- First posted
- 2018-02-12
- Last updated
- 2018-02-12
Source: ClinicalTrials.gov record NCT03430414. Inclusion in this directory is not an endorsement.