NCT03428139

Alpha Lipoic Acid and Chronic Lumbosacral Radicular Pain

Role of Alpha Lipoic Acid Combined With Pulsed Radiofrequency in Treatment of Chronic Lumbosacral Radicular Pain: Prospective, Randomized Study

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In this study, we try to evaluate the effect of using ALA as an adjuvant treatment in patients scheduled for pulsed radiofrequency treatment (PRFT) of the affected dorsal root ganglion (DRG) for treatment of Lumbo-Sacral radicular pain.

Detailed description

Study design: The study is prospective, randomized, and open label started in August 2013 and was completed in March 2017 at Assiut University Hospital, Pain Unit after local ethical committee approval. All patients were informed verbally and in writing about the study, and they signed a detailed written informed consent about the procedure and the nature of the study.

Conditions

• Radicular; Neuropathic, Lumbar, Lumbosacral

Interventions

Type	Name	Description
PROCEDURE	pulsed radiofrequency	Each patient in this group was treated with PRFT on the affected DRG at 42°C for 120 seconds.
DRUG	pulsed radiofrequency plus alpha lipoic acid	Each patient in this group was treated with PRFT as in group I plus oral alpha lipoic acid (ALA) 600 mg (Thiotacid 600 mg, EVA PHARMA, Egypt) three times per day (1800mg/day) for 3 weeks then 600mg once daily for 2 weeks.

Timeline

• Start date: 2013-08-20
• Primary completion: 2017-03-03
• Completion: 2017-09-08
• First posted: 2018-02-09
• Last updated: 2018-02-09

Locations

1 site across 1 country: Egypt