Trials / Active Not Recruiting
Active Not RecruitingNCT03426904
Neoadjuvant FOLFOX Chemotherapy for Patients With Locally Advanced Colon Cancer
Neoadjuvant Chemotherapy for Non-metastatic Locally Advanced Colon Cancer: A Prospective Multicenter Randomized Controlled Trial
- Status
- Active Not Recruiting
- Phase
- Phase 3
- Study type
- Interventional
- Enrollment
- 708 (estimated)
- Sponsor
- Kyungpook National University Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
The main cause of recurrence after surgical treatment of colon cancer is distant metastasis. Neoadjuvant chemotherapy has potential benefits of improving the effectiveness of chemotherapy. Preoperative chemotherapy may eradicate microscopic metastatic cancer cells earlier than adjuvant chemotherapy, reduce cancer cell spillage during surgery, and lessen the invasiveness of surgical resection. This randomized multicenter phase III trial is assessing whether preoperative chemotherapy improves oncologic outcomes of patients with locally advanced colon cancer.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Neoadjuvant FOLFOX | 4 cycles of FOLFOX neoadjuvant chemotherapy and 8 cycles of postoperative chemotherapy |
| DRUG | Conventional adjuvant FOLFOX | 12 cycles of postoperative FOLFOX chemotherapy |
Timeline
- Start date
- 2020-10-23
- Primary completion
- 2028-12-28
- Completion
- 2031-12-28
- First posted
- 2018-02-08
- Last updated
- 2026-02-11
Locations
4 sites across 1 country: South Korea
Source: ClinicalTrials.gov record NCT03426904. Inclusion in this directory is not an endorsement.