NCT03426202

The Effect of Modafinil on Affective and Cognitive Processing

The Effect of Modafinil on Neural Processing During the Interference and Feedback Based Learning Task

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University of Electronic Science and Technology of China · Academic / Other
• Sex: Male
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The study aims to examine whether a single dose of modafinil (200mg, p.o.) can affect feedback-based learning and interference processing in healthy male subjects.

Detailed description

Based on previous animal and human research suggesting a catecholamine-mediated, potentially pro-cognitive, mechanism of action of modafinil, the present study seeks to explore effects of modafinil on feedback-based learning and interference processing in healthy subjects. To this end, the present randomized double-blind, between-subject, placebo-controlled pharmaco-fMRI experiment plans to determine the behavioral and neural effects of a single dose of p.o.modafinil (200mg) versus placebo on validated feedback-based learning and emotional/non-emotional cognitive conflict paradigms. To control for potential effects of pre-medication personality traits as well as effects of modafinil on subjective task performance, subjects will be administered pre-treatment assessing relevant personality traits and post-treatment assessments of meta-cognitive confidence estimation.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Modafinil Oral Tablet	modafinil 200mg
DRUG	Placebo Oral Tablet	placebo 200mg

Timeline

• Start date: 2018-01-01
• Primary completion: 2020-01-01
• Completion: 2020-07-01
• First posted: 2018-02-08
• Last updated: 2019-06-17

Locations

1 site across 1 country: China