Trials / Unknown
UnknownNCT03422614
Pathophysiology of Inborn Immunodeficiencies
Pathophysiologie Angeborener Immundefekte
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 300 (estimated)
- Sponsor
- University of Zurich · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Accepted
Summary
The pathophysiology of primary immunodeficiencies (PID), which encompass a broad range of different diseases with susceptibility to infection and/or a deregulated inflammatory response, is poorly understood. Available treatments are often not specific for a distinct target and might be associated with side effects. To elucidate pathophysiology of different PIDs, stool, urine, blood, tissue biopsies and/or bone marrow will be collected and analysed for anti-microbial activity and inflammatory response. In a second step, targeted treatment for different PIDs might be developed preclinically and ex vivo according to underlying pathophysiology.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Diagnostic Test | Characterisation of cellular and functional phenotype in different PIDs |
Timeline
- Start date
- 2015-07-01
- Primary completion
- 2025-07-01
- Completion
- 2025-07-01
- First posted
- 2018-02-06
- Last updated
- 2018-02-06
Locations
1 site across 1 country: Switzerland
Source: ClinicalTrials.gov record NCT03422614. Inclusion in this directory is not an endorsement.