NCT03419273

Adipose Tissue Inflammation in Individuals Undergoing Bariatric Surgery

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 84 (actual)
• Sponsor: University of Missouri-Columbia · Academic / Other
• Sex: All
• Age: 21 Years – 65 Years
• Healthy volunteers: Accepted

Summary

A growing body of work done over the past few decades has established that adipose tissue as an active endocrine organ which secretes a wide range of metabolic and immunological factors collectively called "adipokines (1)." Importantly, these secreted factors enter into the circulation and have paracrine and autocrine actions, which profoundly impact systemic metabolism (e.g., insulin sensitivity). Additionally, in animals, loss of ovarian hormone production via ovariectomy (similar to menopause in humans) leads to increases in both in adipose tissue mass and in adipose tissue inflammation (2) making this tissue less healthy than that from premenopausal animals. To date, no studies have investigated the effect of menopause on abdominal fat in overweight individuals. Knowing if adipose tissue-specific changes occur with menopause may potentially lead to recommendations or therapeutics to improve women's health post menopause.

Detailed description

Subjects will just have to agree to having a small amount of adipose tissue being removed during the bariatric surgery. The investigators will also collect a blood sample at that time. There will be no other visits for the subject.

Conditions

• Obesity, Morbid
• Bariatric Surgery Candidate

Interventions

Type	Name	Description
PROCEDURE	bariatric surgery	We are recruiting only those going through bariatric surgery

Timeline

• Start date: 2017-07-01
• Primary completion: 2019-03-31
• Completion: 2019-07-01
• First posted: 2018-02-01
• Last updated: 2019-10-03

Locations

1 site across 1 country: United States