NCT03416803

A Study of Individualized Radiotherapy Based on a Prediction Model of Lymph Node Metastasis in Hepatocellular Carcinoma

Prediction of Lymph Node Metastasis in Hepatocellular Carcinoma and the Study of Individualized Radiotherapy

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: Shanghai Zhongshan Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Objectives: 1. To further validate the predictive efficacy of our established microRNA prediction model of HCC lymph node metastasis. 2. To establish a precise therapeutic mode of prophylactic radiation therapy in high-risk patients with HCC with lymph node metastasis under the guidance of a microRNA prediction model.

Detailed description

First, screening out patients who underwent hepatic tumor resection and pathologically diagnosed as HCC . Then，performing the detection of miR-145, miR-31 and miR-92a by using the HCC lymph node metastasis microRNA correlation prediction model established in our previous study. The patients are judged as high risk of lymph node metastasis and low risk Patients, then high-risk patients under the condition of informed consent into the group, randomized into treatment group and control groups. Last, Patients enrolled in the treatment group were treated with radiotherapy and followed up.

Conditions

• Lymph Node Metastasis
• Hepatocellular Carcinoma
• Radiotherapy

Interventions

Type	Name	Description
RADIATION	Radiotherapy	Radiotherapy

Timeline

• Start date: 2018-02-01
• Primary completion: 2019-12-31
• Completion: 2020-06-30
• First posted: 2018-01-31
• Last updated: 2018-02-05

Locations

1 site across 1 country: China