NCT03414476

Demonstration of Carbonyl Stress on Hair Follicles

Demonstration of the Presence of Carbonyl Stress in the Hair Follicles of Women With Reactive Hair Loss

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Pierre Fabre Dermo Cosmetique · Industry
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

In this study, the investigator will try to highlight the presence of carbonyl compounds in the hair follicles of women with telogen effluvium (ET) linked to stress of various origins (fatigue, infectious diseases, emotional stress ...).

Detailed description

At the cutaneous level, oxidative stress induces the formation of carbonyl compounds which, by binding to proteins, produce nonfunctional adducts inducing cutaneous aging. Is this mechanism, called "Carbonyl stress", also present in the scalp and can it be one of the mechanisms involved in the occurrence of reactive hair loss ? To demonstrate this, samples of hair follicles are made. The proteins are extracted from the samples and then assayed. The oxidized (carbonyl) proteins are labeled with specific fluorescent probes.

Conditions

• Effluvium; Telogen

Interventions

Type	Name	Description
OTHER	Hair follicles sampling	The follicles will be collected by lock of 10 hair on the scalp (centro-parietal part), to obtain 40 follicles with epithelial sheath

Timeline

• Start date: 2018-03-26
• Primary completion: 2018-06-25
• Completion: 2018-06-25
• First posted: 2018-01-30
• Last updated: 2020-01-21

Locations

6 sites across 1 country: France