NCT03410342

The Effects of Types of Fruits and Vegetables on Vascular Function

The Effects of Types of Fruits and Vegetables on Vascular Function in Prehypertensive Participants: a Pilot Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: University of Cambridge · Academic / Other
• Sex: All
• Age: 40 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The CIRCUS study is a randomised controlled, cross-over trial to evaluate the effects of increased intakes of citrus fruits and cruciferous vegetables on vascular function in 36 untreated, prehypertensive participants.

Detailed description

The study comprises three 14-day dietary intervention periods, preceded by one week run-in period and separated by one week wash-out periods, 9 weeks in total. The diet will be fully controlled and provided by the researchers. Participants will receive in random order three interventions: * 1 portion of fruits plus 1 portion of vegetables, of commonly consumed types per day. Intakes are at 25th percentile of UK consumption and will exclude citrus fruits, cruciferous and allium vegetables. * 4 portions of fruits plus 4 portions of vegetables, of commonly consumed types per day excluding citrus fruits, cruciferous and allium vegetables. * 4 portions of citrus fruits plus 4 portions of cruciferous vegetables per day.

Conditions

• Blood Pressure
• Vascular Stiffness
• Cardiovascular Risk Factor

Interventions

Type	Name	Description
OTHER	LFV	1 apple/banana/small bunch of grapes per day plus 1 portion of carrot/pepper/tomato per day
OTHER	HFV	4 portions of fruits (apples, bananas, grapes, pears) plus 4 portions of vegetables (carrots, cucumber, sweet peppers, tomatoes), of commonly consumed types per day excluding citrus fruits, cruciferous and allium vegetables.
OTHER	CC	4 portions of citrus fruits (clementines, grapefruits, lemons, oranges) plus 4 portions of cruciferous vegetables (broccoli, brussels sprouts, cauliflower, kale, savoy cabbage) per day.

Timeline

• Start date: 2017-09-04
• Primary completion: 2021-06-21
• Completion: 2021-06-21
• First posted: 2018-01-25
• Last updated: 2022-03-22

Locations

2 sites across 1 country: United Kingdom